6.5 AGEs
Summary
Another part of the cascade of events initiated by hyperglycemia and oxidative stress is the formation of advanced glycation end-products (AGEs). AGEs are formed at a slow rate in normal individuals, but in diabetes, due to the increased availability of glucose, their formation is accelerated. Hyperglycemia induces nonenzymatic glycation of proteins to form AGE, possibly contributing to loss of retinal perictyes, formation of microaneurysms, and damage to the vascular endothelium.
Quiz Module 6.5
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1. AGEs are present in normal individuals, but in diabetes
2. The formations of AGEs may cause the following effect in the retina: