6.7 Hexosamine Pathway


The hexosamine pathway is another downstream consequence of oxidative stress. As described in the Oxidative Stress submodule, Brownlee proposed oxidative stress as a unifying mechanism that links all the damaging biochemical pathways induced in diabetic retinopathy by hyperglycemia. That theory holds that overproduction of reactive oxygen species by mitochondria is the single upstream event that activates four separate metabolic pathways: increased intracellular production of AGEs, PKC activation, increased flux in the polyol pathway, and overactivation of the hexosamine pathway

Quiz Module 6.7

1. In hyperglycemia-induced oxidative stress, the metabolism of glucose is

2. The reactions in the hexosamine pathway in diabetes lead to