6.4 Oxidative Stress


Oxidative stress can be defined as an imbalance between oxygen free radicals, or reactive oxygen species (ROS), and the antioxidant defenses of a biologic system. Mounting evidence suggests that localized oxidative stress due to diabetes-induced metabolic abnormalities is an important mechanism associated with the pathogenesis of diabetic retinopathy. Increases in concentrations of reactive oxygen species (ROS) within ganglion cells lead to the activation of several pathologic mechanisms involved in diabetic retinopathy. Notably, the damage or dysfunction caused by oxidative stress persists even after glycemia has been normalized.

Quiz Module 6.4

1. A number of the biochemical mechanisms that contribute to the pathogenesis of diabetic retinopathy appear to be associated with

2. Oxidative stress constitutes a unifying mechanism that can be linked to all of the damaging mechanisms in diabetic retinopathy induced by: