6.6 Polyol Pathway


The polyol pathway, also called the sorbitol-aldose reductase pathway, metabolizes excess glucose in diabetes. The enzyme aldose reductase, converts glucose to intracellular sorbitol, the first step in the pathway, using nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor. In this process, NADPH is converted to NADP+. Sorbitol, incapable of crossing cellular membranes, accumulates in the cell and is then oxidized to fructose by sorbitol dehydrogenase, producing NADH from NAD+.

Quiz Module 6.6

1. Metabolization of excess glucose in the polyol pathway leads to multiple intracellular problems in diabetes, except

2. The fructose produced in the polyol reactions can be converted into strong glycating agents that can lead to