Syllabus
Curriculum Outline:
Module 1 - Background
- 1.0 Introduction
- 2.0 Introduction
- 2.1 Diabetes Epidemiology
- 2.2 Pre-diabetes
- 2.3 Metabolic Syndrome
- 2.4 Diabetes Risk Factors
- 2.5 Diabetes Complications
- 2.6 Summary
- 3.0 Introduction
- 3.1 Epidemiology
- 3.2 DR/DME Risk Factors
- 3.3 Summary
- 4.0 Introduction
- 4.1 Healthy Blood Vessels
- 4.2 Stimulating Growth
- 4.3 VEGF and Vessel Permeability
- 4.4 Role of Blood Vessels in Ocular Disease
- 4.5 Summary
- 5.0 Introduction
- 5.1 The Human Eye and Retinal Structure
- 5.2 Retinal Vasculature
- 5.3 Retinal Cell Types that Produce VEGF
- 5.4 Summary
- 6.0 Introduction
- 6.1 Metabolic Pathway to DME
- 6.2 Hyperglycemia
- 6.3 PKC
- 6.4 Oxidative Stress
- 6.5 AGEs
- 6.6 Polyol Pathway
- 6.7 Hexosamine Pathway
- 6.8 R-A System
- 6.9 Inflammation
- 6.10 Retinal Vessel Changes (include hypertension)
- 6.11 Retinal Changes and Edema
- 6.12 Summary
Module 7 - DR/DME Diagnosis
- 7.0 Introduction
- 7.1 Color Fundus Photography
- 7.2 Fluorescein Angiography
- 7.3 Ocular Coherence Tomography
- 7.4 Other types of OCT
- 7.5 The future of Detection
- 7.6 Symptoms and Onset
- 7.7 Summary
- 8.0 Introduction
- 8.1 DR Severity Scale
- 8.2 DME Classifications
- 8.3 Proposed Phenotypes of DR/DME
- 8.4 Summary
- 9.0 Introduction
- 9.1 Anti-VEGF Treatments
- 9.2 Biology and pharmacology of anti-VEGF therapies
- 9.3 Avastin
- 9.4 Lucentis
- 9.5 Eylea
- 9.6 Side Effects
- 9.7 Laser Therapy
- 9.8 Corticosteroids
- 9.9 Vitrectomy
- 9.10 Future Technology
- 9.11 Assessment of treatment value
- 9.12 Summary
- 10.0 Introduction
- 10.1 READ-2
- 10.2 RESOLVE
- 10.3 FAME
- 10.4 BOLT
- 10.5 DRCR.net Protocol I
- 10.6 CHAMPLAIN
- 10.7 RIDE/RISE
- 10.8 PLACID
- 10.9 MEAD
- 10.10 RESTORE
- 10.11 VIVID/VISTA
- 10.12 DRCR.net Protocol T
- 10.13 Ongoing Studies
- 10.14 Summary: Putting It All Together