Syllabus


Curriculum Outline:

Module 1 - Background
  • 1.0 Introduction
Module 2 - Diabetes
  • 2.0 Introduction
  • 2.1 Diabetes Epidemiology
  • 2.2 Pre-diabetes
  • 2.3 Metabolic Syndrome
  • 2.4 Diabetes Risk Factors
  • 2.5 Diabetes Complications
  • 2.6 Summary
Module 3 - Diabetic Eye Disease
  • 3.0 Introduction
  • 3.1 Epidemiology
  • 3.2 DR/DME Risk Factors
  • 3.3 Summary
Module 4 - Role of Blood Vessels
  • 4.0 Introduction
  • 4.1 Healthy Blood Vessels
  • 4.2 Stimulating Growth
  • 4.3 VEGF and Vessel Permeability
  • 4.4 Role of Blood Vessels in Ocular Disease
  • 4.5 Summary
Module 5 - The Retina
  • 5.0 Introduction
  • 5.1 The Human Eye and Retinal Structure
  • 5.2 Retinal Vasculature
  • 5.3 Retinal Cell Types that Produce VEGF
  • 5.4 Summary
Module 6 - DR/DME Etiology
  • 6.0 Introduction
  • 6.1 Metabolic Pathway to DME
  • 6.2 Hyperglycemia
  • 6.3 PKC
  • 6.4 Oxidative Stress
  • 6.5 AGEs
  • 6.6 Polyol Pathway
  • 6.7 Hexosamine Pathway
  • 6.8 R-A System
  • 6.9 Inflammation
  • 6.10 Retinal Vessel Changes (include hypertension)
  • 6.11 Retinal Changes and Edema
  • 6.12 Summary
Module 7 - DR/DME Diagnosis
  • 7.0 Introduction
  • 7.1 Color Fundus Photography
  • 7.2 Fluorescein Angiography
  • 7.3 Ocular Coherence Tomography
  • 7.4 Other types of OCT
  • 7.5 The future of Detection
  • 7.6 Symptoms and Onset
  • 7.7 Summary
Module 8 - DR/DME Classifications
  • 8.0 Introduction
  • 8.1 DR Severity Scale
  • 8.2 DME Classifications
  • 8.3 Proposed Phenotypes of DR/DME
  • 8.4 Summary
Module 9 - Treatments
  • 9.0 Introduction
  • 9.1 Anti-VEGF Treatments
  • 9.2 Biology and pharmacology of anti-VEGF therapies
  • 9.3 Avastin
  • 9.4 Lucentis
  • 9.5 Eylea
  • 9.6 Side Effects
  • 9.7 Laser Therapy
  • 9.8 Corticosteroids
  • 9.9 Vitrectomy
  • 9.10 Future Technology
  • 9.11 Assessment of treatment value
  • 9.12 Summary
Module 10 - Clinical Studies & Treatment Data
  • 10.0 Introduction
  • 10.1 READ-2
  • 10.2 RESOLVE
  • 10.3 FAME
  • 10.4 BOLT
  • 10.5 DRCR.net Protocol I
  • 10.6 CHAMPLAIN
  • 10.7 RIDE/RISE
  • 10.8 PLACID
  • 10.9 MEAD
  • 10.10 RESTORE
  • 10.11 VIVID/VISTA
  • 10.12 DRCR.net Protocol T
  • 10.13 Ongoing Studies
  • 10.14 Summary: Putting It All Together